業績 / Publication

Saito, Y., Osako, Y., Odagawa, M., Oisi, Y., Matsubara, C., Kato, S., Kobayashi, K., Morita, M., Johansen, J.P., and Murayama, M. (2025).

Amygdalo-cortical dialogue underlies memory enhancement by emotional association.

Neuron 113, 931-948.e7.

森田光洋 (2025).

光を用いた生命現象の操作.

光学 54, 35–37.

Fujii, R., Nambu, Y., Sawant Shirikant, N., Furube, E., Morita, M., Yoshimura, R., and Miyata, S. (2024).

Neuronal regeneration in the area postrema of adult mouse medulla oblongata following glutamate-induced neuronal elimination.

Neuroscience 563, 188–201.

森田光洋 (2024).

生命活動の蛍光イメージングの歴史.

光学 53, 432–437.

Matsuda, H., Tsuji, E., Riberu, A.A.O., Okano, H., and Morita, M. (2024).

Glial scar formation by reactive astrocytes derived from oligodendrocyte progenitor cells after closed-head injury.

bioRxiv, 2024.09.16.613178. https://doi.org/10.1101/2024.09.16.613178.

Sawant, N., Watanabe, A., Ueda, H., Okano, H. & Morita, M.

Incomplete accumulation of perilesional reactive astrocytes exacerbates wound healing after closed-head injury by increasing inflammation and BBB disruption.

bioRxiv, 2024.09.16.613178. https://doi.org/10.1101/2024.09.16.613178.

Morita, M.

Modern Microscopic Approaches to Astrocytes.

Int. J. Mol. Sci. 24, (2023)

Azuma, M., Lee, H., Shinzaki, K., Yamane, R. & Morita, M.

Cortical-wide impairment of ‘The Glymphatic system’ after focal brain injury.

bioRxiv 2022.10.05.510560 (2022) doi:10.1101/2022.10.05.510560

Okada, S., Kobayashi, M., Lee, H. & Morita, M.

Crosstalk between AQP4-dependent ATP/Adenosine release and dopamine neurotransmission in depressive behavior during cocaine withdrawal.

bioRxiv 2022.10.03.510559 (2022) doi:10.1101/2022.10.03.510559

Kato, D. et al.

Evaluation and Manipulation of Neural Activity using Two-Photon Holographic Microscopy.

J. Vis. Exp. (2022) doi:10.3791/64205

Kumar, M. et al.

Quantitative dynamic evolution of physiological parameters of RBC by highly stable digital holographic microscopy.

Opt. Lasers Eng. 151, 106887 (2022)

的場修，全香玉，米田成，森田光洋

2光子励起ホログラフィック顕微鏡による高度光遺伝学応用

レーザー研究，vol50(11), p633-638 (2022)

Nambu, Y. et al.

Effects of leptin on proliferation of astrocyte- and tanycyte-like neural stem cells in the adult mouse medulla oblongata.

Neurosci. Res.(2021) doi:10.1016/j.neures.2021.05.012

森田光洋，安井正人

Glymphatic system 研究の現状から見たアクアポリンとアルツハイマー病の関連

実験医学（増刊号）「神経免疫　メカニズムと疾患」 39(15)p2399-2402（2021）

Furube, E. et al.

Neural stem cell phenotype of tanycyte-like ependymal cells in the circumventricular organs and central canal of adult mouse brain.

Sci. Rep. 10, 2826 (2020)

Potokar, M., Morita, M., Wiche, G. & Jorgačevski, J.

The Diversity of Intermediate Filaments in Astrocytes.

Cells 9, (2020)

Rajput, S. K. et al.

Three-dimensional fluorescence imaging using the transport of intensity equation.

J. Biomed. Opt. 25, 1–7 (2019)

Hiratsuka, D., Kurganov, E., Furube, E., Morita, M. & Miyata, S.

VEGF- and PDGF-dependent proliferation of oligodendrocyte progenitor cells in the medulla oblongata after LPC-induced focal demyelination.

J. Neuroimmunol. 332, 176–186 (2019)

Morita, M. et al.

Metabolic Plasticity of Astrocytes and Aging of the Brain.

Int. J. Mol. Sci. 20, (2019)

Hiratsuka, D. et al.

Remyelination in the medulla oblongata of adult mouse brain during experimental autoimmune encephalomyelitis.

J. Neuroimmunol. 319, 41–54 (2018)

Ueno, S., Miyoshi, H., Maruyama, Y., Morita, M. & Maekawa, S.

Interaction of dynamin I with NAP-22, a neuronal protein enriched in the presynaptic region.

Neurosci. Lett. 675, 59–63 (2018)

Maruyama, Y., Ueno, S., Morita, M., Hayashi, F. & Maekawa, S.

Inhibitory effect of several sphingolipid metabolites on calcineurin.

Neurosci. Lett. 673, 132–135 (2018)

Takagi, S., Furube, E., Nakano, Y., Morita, M. & Miyata, S.

Microglia are continuously activated in the circumventricular organs of mouse brain.

J. Neuroimmunol. 331, 74–86 (2017)

Fujii, Y., Maekawa, S. & Morita, M.

Astrocyte calcium waves propagate proximally by gap junction and distally by extracellular diffusion of ATP released from volume-regulated anion channels.

Sci. Rep. 7, 13115 (2017)

Sakai, Y., Asakura, Y., Morita, M. & Takahashi, T.

Concise Synthesis of Hydroxy β-Methyl Fatty Acid Ethyl Esters.

Chem. Pharm. Bull. 65, 1195–1198 (2017)

Yamashiro, K. & Morita, M.

Novel aspects of extracellular adenosine dynamics revealed by adenosine sensor cells.

Neural Regeneration Res. 12, 881–885 (2017)

Yamashiro, K., Fujii, Y., Maekawa, S. & Morita, M.

Multiple pathways for elevating extracellular adenosine in the rat hippocampal CA1 region characterized by adenosine sensor cells.

J. Neurochem. 140, 24–36 (2016)

Morita, M., Nakane, A., Fujii, Y., Maekawa, S. & Kudo, Y.

High Cell Density Upregulates Calcium Oscillation by Increasing Calcium Store Content via Basal Mitogen-Activated Protein Kinase Activity.

PLoS One 10, e0137610 (2015)

Kobayashi, Y. et al.

Ganglioside contained in the neuronal tissue-enriched acidic protein of 22 kDa (NAP-22) fraction prepared from the detergent-resistant membrane microdomain of rat brain inhibits the phosphatase activity of calcineurin.

J. Neurosci. Res. 93, 1462–1470 (2015)

Morita, M., Nakane, A., Maekawa, S. & Kudo, Y.

Pharmacological characterization of the involvement of protein kinase C in oscillatory and non-oscillatory calcium increases in astrocytes.

J. Pharmacol. Sci. 129, 38–42 (2015)

Maekawa, S., Kobayashi, Y., Morita, M. & Suzaki, T.

Tight binding of NAP-22 with acidic membrane lipids.

Neurosci. Lett. 600, 244–248 (2015)

Furube, E., Morita, M. & Miyata, S.

Characterization of neural stem cells and their progeny in the sensory circumventricular organs of adult mouse.

Cell Tissue Res. 362, 347–365 (2015)

森田光洋

新規脳傷害モデル「光傷害」における脳組織再生とグリア細胞の活性化

脳循環代謝 25 p63-66 (2014)

Maekawa, S. et al.

Interaction of NAP-22 with brain glutamic acid decarboxylase (GAD).

Neurosci. Lett. 537, 50–54 (2013)

Maimaitiyiming, M. et al.

Identification of dynamin as a septin-binding protein.

Neurosci. Lett. 534, 322–326 (2013)

Maimaitiyiming, M., Kumanogoh, H., Nakamura, S., Morita, M. & Maekawa, S.

Structures of septin filaments prepared from rat brain and expressed in bacteria.

Protein Expr. Purif. 87, 67–71 (2013)

Suzuki, T., Sakata, H., Kato, C., Connor, J. A. & Morita, M.

Astrocyte activation and wound healing in intact-skull mouse after focal brain injury.

Eur. J. Neurosci. 36, 3653–3664 (2012)

Takaichi, R. et al.

Inhibitory effect of NAP-22 on the phosphatase activity of synaptojanin-1.

J. Neurosci. Res. 90, 21–27 (2011)

Morita, M. & Kudo, Y.

Growth factors upregulate astrocyte [Ca2+]i oscillation by increasing SERCA2b expression.

Glia 58, 1988–1995 (2010)

Morita, M., Yoshizaki, K., Nakane, A. & Kudo, Y.

Inhibitory effect of the phosphoinositide 3-kinase inhibitor LY294002 on muscarinic acetylcholine receptor-induced calcium entry in PC12h cells.

J. Pharmacol. Sci. 105, 258–263 (2007)

Morita, M. et al.

Dual regulation of astrocyte gap junction hemichannels by growth factors and a pro-inflammatory cytokine via the mitogen-activated protein kinase cascade.

Glia 55, 508–515 (2007)

Morita, M., Yoshiki, F., Nakane, A., Okubo, Y. & Kudo, Y.

Receptor- and calcium-dependent induced inositol 1,4,5-trisphosphate increases in PC12h cells as shown by fluorescence resonance energy transfer imaging.

FEBS J. 274, 5147–5157 (2007)

Kozuka, N., Kudo, Y. & Morita, M.

Multiple inhibitory pathways for lipopolysaccharide- and pro-inflammatory cytokine-induced nitric oxide production in cultured astrocytes.

Neuroscience 144, 911–919 (2007)

Blagoev, K. B. et al.

Modelling the magnetic signature of neuronal tissue.

Neuroimage 37, 137–148 (2007)

Yoshida, Y. et al.

Effects of bifemelane on the calcium level and ATP release of the human origin astrocyte clonal cell.

J. Pharmacol. Sci. 102, 121–128 (2006)

Hirabayashi, M. et al.

No effect of recombinase-mediated DNA transfer on production efficiency of transgenic rats.

Exp. Anim. 55, 131–135 (2006)

Yoshida, Y., Nakane, A., Morita, M. & Kudo, Y.

A novel effect of bifemelane, a nootropic drug, on intracellular Ca2+ levels in rat cerebral astrocytes.

J. Pharmacol. Sci. 100, 126–132 (2006)

Morita, M. et al.

Use of the exogenous Drosophila octopamine receptor gene to study Gq-coupled receptor-mediated responses in mammalian neurons.

Neuroscience 137, 545–553 (2006)

Kozuka, N., Itofusa, R., Kudo, Y. & Morita, M.

Lipopolysaccharide and proinflammatory cytokines require different astrocyte states to induce nitric oxide production.

J. Neurosci. Res. 82, 717–728 (2005)

Morita, M., Kozuka, N., Itofusa, R., Yukawa, M. & Kudo, Y.

Autocrine activation of EGF receptor promotes oscillation of glutamate-induced calcium increase in astrocytes cultured in rat cerebral cortex.

J. Neurochem. 95, 871–879 (2005)

Nakahara, M. et al.

A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme.

J. Biol. Chem. 280, 29128–29134 (2005)

Yoshida, Y. et al.

Ca2+-dependent induction of intracellular Ca2+ oscillation in hippocampal astrocytes during metabotropic glutamate receptor activation.

J. Pharmacol. Sci. 97, 212–218 (2005)

森田光洋, 工藤佳久

グリア細胞におけるカルシウムダイナミックス「グリア細胞－その新しい展望」

Clinical Neuroscience, vol. 23(2), p148-152 (2005)

森田光洋

柔軟な脳の働きを支えるアストロサイト

季刊 生命誌 48号春 (2005)

Muroyama, A. et al.

A novel variant of ionotropic glutamate receptor regulates somatostatin secretion from delta-cells of islets of Langerhans.

Diabetes 53, 1743–1753 (2004)

Morita, M., Susuki, J., Moto, T., Higuchi, C. & Kudo, Y.

A novel method to quantify calcium response pattern and oscillation using fura2 and acridine orange.

J. Pharmacol. Sci. 94, 25–30 (2004)

工藤佳久, 森田光洋

カルシウムイメージング機器の現状，「バイオ高性能機器・新技術利用マニュアル（小原，谷口，市川，異界編）」

蛋白質核酸酵素, 2004年8月号増刊, vol. 49, No.11, p1623-1640 (2004)

Morita, M. et al.

Dual Regulation of Calcium Oscillation in Astrocytes by Growth Factors and Pro-Inflammatory Cytokines via the Mitogen-Activated Protein Kinase Cascade.

Journal of Neuroscience 23, 10944–10952 (2003)

Morita, M., Yoshiki, F. & Kudo, Y.

Simultaneous imaging of phosphatidyl inositol metabolism and Ca2+ levels in PC12h cells.

Biochem. Biophys. Res. Commun. 308, 673–678 (2003)

Yoshida, Y. et al.

Expression of group I metabotropic glutamate receptors in rat hippocampal cells in culture and their characterization by intracellular calcium ion dynamics.

J. Pharmacol. Sci. 92, 245–251 (2003)

工藤佳久, 森田光洋, 宮川博義

グリア－ニューロン回路網の存在と脳機能発現への関与 (Glia-Neuron Network and Their Roles in the Brain Function)

細胞工学 (Cell Technology)，22(4)，p393-398 (2003)

Tsuchiya, R., Yoshiki, F., Kudo, Y. & Morita, M.

Cell type-selective expression of green fluorescent protein and the calcium indicating protein, yellow cameleon, in rat cortical primary cultures.

Brain Res. 956, 221–229 (2002)

森田光洋

細胞機能分子の可視化解析

化学工業, Vol.53, No.5, p.384-389 (2002)

工藤佳久, 吉田佳督, 森田光洋

アストロサイトとニューロンのクロストークとその生理的意義

脳機能の解明－生命科学の主潮流（赤池，東，阿部，久保編）, p165-170 (2002)

Yatsushiro, S., Hayashi, M., Morita, M., Yamamoto, A. & Moriyama, Y.

Glutamate receptor subunit delta2 is highly expressed in a novel population of glial-like cells in rat pineal glands in culture.

J. Neurochem. 75, 1115–1122 (2000)

Hirasawa, T. et al.

Adverse effects of an active fragment of parathyroid hormone on rat hippocampal organotypic cultures.

Br. J. Pharmacol. 129, 21–28 (2000)

森田光洋, 工藤佳久

グリア細胞の性質と機能

生物物理, vol.224, p211-216 (1999)

森田光洋

生体内タンパク質の化学的蛍光標識法―光計測による生理学の新たな展開

化学と工業, vol. 52-11, p1420-1 (1999)

Hirasawa, T. et al.

Activation of dihydropyridine sensitive Ca2+ channels in rat hippocampal neurons in culture by parathyroid hormone.

Neurosci. Lett. 256, 139–142 (1998)

Kudo, Y., Morita, M. and Higashi, H.

Visualization of kinase activity in theliving cells

The Adrenal Chromaffin Cell. Hokkaido Univ. Press, p363-374, ISBN4-8329-0267-9 (1998)

工藤佳久, 森田光洋, 東　秀好

細胞内酵素活性の可視化解析法

病理と臨床, 16，1323-1326 (1998)

Yoshikawa, F. et al.

Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor.

J. Biol. Chem. 271, 18277–18284 (1996)

Yamada, H. et al.

Microvesicle-mediated exocytosis of glutamate is a novel paracrine-like chemical transduction mechanism and inhibits melatonin secretion in rat pinealocytes.

J. Pineal Res. 21, 175–191 (1996)

Llinas, R. et al.

The inositol high-polyphosphate series blocks synaptic transmission by preventing vesicular fusion: a squid giant synapse study.

Proc. Natl. Acad. Sci. U. S. A. 91, 12990–12993 (1994)

Llinas, R. et al.

Transmission at the squid giant synapse was blocked by tetanus toxin by affecting synaptobrevin, a vesicle-bound protein.

J. Physiol. 477 (Pt 1), 129–133 (1994)